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Skin pain receptors: For a long time it was thought that the sense of feeling and pain was dependent on the brain. However, it has been discovered that there are pain receptors present in the skin. Without these pain receptors, a person would not be able to feel pain.

We shall send those who reject our revelations to the (hell) fire. When their skins have been burned away, We shall replace them with new ones so that they may continue to feel the pain: God is almighty all-wise.” [4:56].